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Chỉ định và Liều dùng
Oral
Mild to moderate pain Adult: Each tablet containing paracetamol 650 mg and pentazocine 25 mg: 1 tablet every 4 hr. Max: 6 tablets/day.
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Chống chỉ định
Hypersensitivity to either component; raised intercranial pressure or head injury.
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Thận trọng
Head injury, other intracranial lesions or preexisting increase in intracranial pressure (impedes pupillary response required for neurological assessment); patients on opiate analgesics; opioid dependence; acute alcoholism; compromised respiratory, cardiac, renal or hepatic functions; epileptic patients; pregnancy & lactation, children. Caution when used in patients with MI who have accompanying nausea or vomiting. May experience withdrawal symptoms after receiving pentazocine.
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Tác dụng không mong muốn
Nausea, vomiting, constipation, anorexia, diarrhea, dizziness, sedation, disorientation, euphoria, headache, visual blurring, rarely dysphoria, sweating, flushing, rashes & urticaria; urinary retention, anaphylactoid reaction & drug abuse & dependence.
Potentially Fatal: Hepatic necrosis (especially in chronic alcoholics). |
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Quá liều
Symptoms of overdose would be a combination of those observed with pentazocine overdose and paracetamol overdose. Pentazocine overdose may lead to anxiety, nightmares, strange thoughts and hallucinations. Marked respiratory depression associated with increased BP and tachycardia may also occur. Acute paracetamol overdose may cause nausea, vomiting, anorexia and abdominal pain. Severe overdosage may lead to potentially fatal hepatic necrosis. Treatment involves oxygen, IV fluids, vasopressors and other supportive measures.
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Tương tác
Paracetamol may also enhance anticoagulant activity. Naloxone reverses effects of pentazocine.
Potentially Fatal: Alcohol & other CNS depressants potentiate depressant action of pentazocine. |
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Tác dụng
Description:
Mechanism of Action: Pentazocine is an opioid analgesic with agonist/antagonist action. Paracetamol is a centrally and peripherally acting analgesic and antipyretic. The combination gives additive analgesic effects. Pharmacokinetics: Absorption: Pentazocine: Well absorbed from the GI tract. Paracetamol: Rapidly and almost completely absorbed from the GI tract. Distribution: Pentazocine: Passes the placental barrier. Metabolism: Pentazocine: Metabolised mainly by hepatic biotransformation. Paracetamol: Conjugated in the liver with glucuronic acid and to a smaller extent with sulfuric acid. Excretion: Pentazocine: Elimination half-life ranges from 1.5-10 hr. Paracetamol: Elimination half-life ranges from 2-4 hr. |
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Phân loại MIMS
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Đăng xuất
